How to Farm Runes in Diablo 4 Vessel of Hatred DLC

Diablo 4 reintroduces the iconic Runes and Runewords system, accessible only through the Vessel of Hatred DLC.

To access this system, ensure you have the Vessel of Hatred DLC installed and progress through the main story. With the Rune system unlocked you can explore various methods to build a diverse collection, dramatically enhancing your character’s abilities.

Let’s look at all the different types of Runes and how to farm them to unlock your character’s full potential.

1. Farming Runes in Diablo 4 Vessel of Hatred DLC

In Diablo 4 Vessel of Hatred DLC, the classic Rune system from Diablo 2 returns, allowing players to craft powerful Runewords by socketing Runes into gear. These customizable enchantments combine Trigger and Effect mechanics, influenced by Ritual and Invocation Runes.

After completing the “Fundament of Faith” quest in the Vessel of Hatred campaign, players can start collecting Runes. With hundreds of Runes to discover and limitless Runeword combinations, expanding your collection requires participation in specific in-game activities.

Here are eight methods to farm Runes in Diablo IV:

• Conquer Vessel of Hatred campaign bosses.
• Earn Whisper Caches through Tree of Whispers tasks.
• Defeat World Bosses.
• Clear Strongholds.
• Use Tributes in Kurast Undercity.
• Utilize Seething Opal of Socketables.
• Craft at the Jeweler.
• Trade with fellow players.

i. Conquer Vessel of Hatred Campaign Bosses

• The Vessel of Hatred campaign in Diablo 4 offers a reliable method for farming Runes, essential for crafting powerful Runewords.
• As players progress through the engaging storyline, they’ll encounter many powerful bosses that drop valuable Runes upon defeat.
• Players can maximise their Rune farming potential by completing campaign quests efficiently, optimizing gear and skills, and tackling higher difficulty levels.

ii. Earn Whisper Caches through Tree of Whispers tasks

• Diablo 4 players can increase their Rune collection by completing tasks for the Tree of Whispers that reward whisper caches containing Runes.
• The impact of cache quality on Rune rarity is still uncertain, but rumours suggest that Legendary caches may increase the chances of obtaining Legendary Runes.
• As players explore this method, they’ll find it offers a reliable and time-efficient way to accumulate Runes.

iii. Defeat World Bosses

• World Bosses in Diablo 4 provide a challenging yet lucrative opportunity to acquire Runes consistently. Season 6’s revamped difficulty tiers and improved loot have attracted many players.
• With more participants, finding groups is now easier, allowing players to tackle these daunting battles and reap the rewards. Players can reliably accumulate Runes by defeating World Bosses, making this method a strong Rune-farming strategy.
• The collaborative nature of these battles also encourages social interaction and camaraderie among players.

iv. Clear Strongholds

• Clearing Strongholds for the first time rewards players with Magic-quality Rune drops, which, despite being lower-tier, hold significant value.
• These Runes often provide meaningful Offering bonuses for simple actions, such as using a healing potion.
• Farming Strongholds allows players to collect Magic Runes, which can be traded for Rare or Legendary variants, giving way to more powerful Runes.

v. Use Tributes in Kurast Undercity

• Diablo 4’s Kurast Undercity offers a unique rune-farming strategy that uses Tributes.
• Players can ensure a Rune reward upon completion by investing these special items at the outset of an Undercity run, provided they’ve achieved Attunement Rank 1.
• This approach provides a refreshing respite from the unpredictability of other farming methods, guaranteeing Rune drops.

vi. Utilize Seething Opal of Socketables

• In Diablo 4, the Seething Opal of Socketables functions similarly to Elixirs but with the added benefit of stackable effects, allowing players to amplify their gains.
• By utilizing the Seething Opal of Socketables, players can significantly increase the drop rate of Gem Fragments from enemies and, thus, gain a chance to receive Rune drops.
• Players can also reap additional rewards, including accelerated XP gains and enhanced reputation with the Zakarum Remnants.

vii. Craft at the Jeweler

• The Jeweler in Diablo 4 provides a valuable service for players seeking to refresh their Rune collection. Players can craft a new, random Rune by trading three identical unwanted Runes.
• Although the resulting Rune’s rarity may not directly correlate with the traded Runes’, this method allows players to repurpose excess duplicates, reducing inventory clutter and increasing the chances of obtaining desired Runes.

viii. Trade with Fellow players

• In Diablo 4, player-to-player trading creates a community-driven marketplace to strategically acquire and exchange Runes.
• Since Runes aren’t bound to characters, players can swap them freely. This flexibility allows players to hunt specific Runes and forge trade partnerships.
• By networking with fellow players, individuals can consolidate and trade redundant Runes at the Jeweler, optimizing their collections.

2. Runes of Ritual

Name	Rarity	Gain	Use
Yul	Legendary	50 Offering	Cast a Skill with a Cooldown.
Ahu	Legendary	10 Offering	Lucky Hit: Up to a 100% chance against Injured enemies.
Tam	Legendary	25 Offering	Cast a non-Channeled Core Skill.
Xol	Legendary	150 Offering	Evoke power from another Class.
Bac	Legendary	50 Offering	Travel 5 meters.
Lith	Legendary	25 Offering	Stand still for 0.3 seconds.
Cir	Magic	25 Offering	Cast the same non-Channeled Skill 3 times in a row.
Zan	Magic	150 Offering	Cast an Ultimate Skill.
Cem	Magic	50 Offering	Cast Evade.
Ur	Magic	10 Offering	Your Minion or Companion kills an enemy or dies.
Yax	Magic	100 Offering	Drink a Healing Potion.
Moni	Magic	10 Offering	Cast a Skill after moving. (Cooldown: 0.2 seconds)
Neo	Rare	300 Offering	Deal damage after not taking any within 5 seconds. (Resets if Invulnerable)
Feo	Rare	1000 Offering	Become Injured or Crowd Controlled. (Cooldown: 20 seconds)
Noc	Rare	5 Offering	Inflict a Crowd Control that isn’t Slow or Chill.
Poc	Rare	2 Offering	Spend 5% of your Maximum Resource.
Kaa	Rare	2 Offering	Lose 1% of your Maximum Life.

3. Runes of Invocation

Name	Rarity	Requires	Overflow	Cooldown	Use
Ohm	Legendary	500 Offering	Increased Duration	2 Seconds	Evoke the Barbarian’s Enhanced War Cry, increasing your Movement Speed and damage dealt.
Vex	Legendary	400 Offering	Increased Duration	1 Second	Gain +3 to all Skills for 5 seconds.
Xan	Legendary	700 Offering	N/A	1 Second	Your next Skill cast will be a guaranteed Critical Strike and Overpower.
Yom	Legendary	500 Offering	N/A	5 Seconds	Evoke the Druid’s Petrify, Stunning enemies and increasing your Critical Strike Damage against them.
Eom	Legendary	100 Offering	Further Reduced Cooldowns	1 Second	Reduce your active Cooldowns by 0.25 seconds.
Jah	Legendary	500 Offering	N/A	2 Seconds	Replace your next Evade with the Sorcerer’s Teleport, blinking further, dealing damage, and becoming Unstoppable.
Gar	Magic	25 Offering	Gain Multiple Stacks	1 Second	Gain 2.5% Critical Strike Chance for 5 seconds, up to 25%.
Lum	Magic	5 Offering	Increased Resource Restored	1 Second	Restore 1 Primary Resource.
Teb	Magic	100 Offering	N/A	1 Second	Evoke the Necromancer’s Abhorrent Iron Maiden, counterattacking damage from enemies and Healing you when they die.
Ono	Magic	25 Offering	Increased Bolts Spawned	1 Second	Evoke the Druid’s Dancing Bolts, seeking and dealing damage to enemies.
Tec	Magic	100 Offering	Increased Size	1 Second	Evoke the Barbarian’s Earthquake, dealing damage to enemies within.
Met	Magic	100 Offering	Increased Duration	1 Second	You leave the Necromancer’s Desecrated Ground behind you for 3 seconds, dealing damage to enemies within.
Tun	Magic	100 Offering	Increased Grenades Spawned	1 Second	Evoke the Rogue’s Stun Grenades, Stunning and dealing damage to enemies.
Ton	Magic	25 Offering	Increased Meteorites Spawned	1 Second	Evoke the Sorcerer’s Meteorites, dealing damage to enemies.
Tal	Magic	100 Offering	Increased Swarms Spawned	1 Second	Evoke the Spiritborn’s Pestilent Swarm, dealing damage to enemies.
Ceh	Magic	100 Offering	Summon Multiple Wolves	1 Second	Summon a Spirit Wolf to attack enemies for 8 seconds.
Lac	Rare	800 Offering	Increased Duration	1 Second	Evoke the Barbarian’s Challenging Shout, reducing your damage taken.
Que	Rare	800 Offering	Increased Duration	1 Second	Evoke the Druid’s Earthen Bulwark, granting yourself a Barrier.
Qua	Rare	400 Offering	Increased Duration	1 Second	Restore an Evade charge and gain 6% Movement Speed for 5 seconds, up to 30%.
Xal	Rare	200 Offering	Increased Duration	1 Second	Gain 20% Maximum Life for 4 seconds.
Wat	Rare	100 Offering	N/A	1 Second	Evoke the Necromancer’s Horrid Decrepify, Slowing enemies, reducing their damage, and letting you Execute them.
Qax	Rare	400 Offering	Further Increased Damage	1 Second	Your next non-Basic Skill cast spends all of your Primary Resource to deal up to 100% increased damage.
Zec	Rare	200 Offering	Further Reduced Cooldown	2 Seconds	Reduce your active Ultimate Cooldown by 4 seconds.
Ner	Rare	700 Offering	Increased Duration	6 Seconds	Evoke the Rogue’s Countering Concealment, gaining Dodge Chance, Movement Speed, Unstoppable, and Stealth.
Mot	Rare	150 Offering	Gain Multiple Shadows	1 Second	Gain a shadow from the Rogue’s Dark Shroud, reducing damage taken per shadow.
Thul	Rare	400 Offering	Increased Size	1 Second	Evoke the Sorcerer’s Mystical Frost Nova, inflicting Freeze and Vulnerable onto enemies.
Tzic	Rare	250 Offering	N/A	1 Second	Evoke the Spiritborn’s Concussive Stomp, dealing damage and Knocking Down enemies.
Kry	Rare	500 Offering	N/A	3 Seconds	Evoke the Spiritborn’s Vortex, dealing damage and Pulling In enemies.

Now that you’ve uncovered the secrets to successful Rune farming in Diablo 4, it’s time to put your knowledge into action. With these strategies, watch your Rune collection grow!

4. About Diablo IV

Diablo IV, developed and published by Blizzard Entertainment, is the fourth installment in the classic Diablo series. It was announced back in 2019 at BlizzCon. The game was released on June 6, 2023 for PlayStation, Xbox, and PC.

Players fight against the darkness to save the Sanctuary in the brutal battle between the High Heavens and the Burning Hells. You can either play solo or with your friends in the co-op mode.